Director, Medicinal Chemistry
About Arnatar Therapeutics
Arnatar Therapeutics is a clinical stage, mission-driven biotechnology company advancing transformative RNA medicines using best-in-class antisense technology. We combine deep scientific expertise in RNA biology, medicinal chemistry, and translational development to deliver therapies for diseases with high unmet medical need. Our culture prioritizes innovation, scientific rigor, and collaborative problem-solving to accelerate the translation of novel RNA modalities into the clinic.
Position Summary
This position will lead the Medicinal Chemistry department, encompassing oligonucleotide synthesis, extrahepatic delivery innovation, and nucleic acid modification. The role will collaborate closely with subject matter experts across Biology, Pharmacology, and DMPK to support programs from discovery through IND-enabling studies and early clinical development, ensuring scientific excellence, manufacturability, and regulatory readiness.
Key Responsibilities
Technology & Medicinal Chemistry
- Oligonucleotide (DNA/RNA) synthesis, purification, analysis and formulation as needed.
- Lead optimization of antisense oligonucleotide (ASO) chemistry, including backbone, sugar, and conjugation strategies.
- Drive structure–activity relationship (SAR) efforts to improve potency, specificity, safety, and therapeutic index of the platform technology.
- Establish scalable synthetic processes for modified oligonucleotides and conjugates.
Extrahepatic Delivery
- Develop and implement strategies for tissue-selective delivery beyond the liver (e.g., kidney, CNS, muscle, lung, etc.).
- Evaluate and integrate novel targeting platforms and conjugation technologies.
- Align chemistry and delivery approaches with in vivo pharmacology and translational goals.
Leadership & Strategy
- Build and lead high-performing multidisciplinary teams in chemistry and delivery.
- Contribute to corporate strategy as a member of the executive leadership team.
- Support regulatory interactions, partnerships, and scientific communication with investors and advisory boards.
Qualifications
- Ph.D. in Medicinal Chemistry, Organic Chemistry, Pharmaceutical Sciences, or related field.
- 15+ years of industry experience in oligonucleotide therapeutics with progressive leadership roles.
- Proven track record advancing antisense or related RNA therapeutic candidates toward clinical development.
- Deep expertise in oligonucleotide chemistry, conjugation/delivery approaches, analytical characterization, and CMC strategy.
- Experience with extrahepatic delivery solutions.
- Strong leadership, strategic decision-making, and cross-functional collaboration skills.
- Position level depends on experience.